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News breaking: 2017-04-18

Shionogi presenteert op ECCMID 2017 nieuwe gegevens over siderofore cefalosporine Cefiderocol (S-649266) en cap-onafhankelijke endonuclease-inhibitor S-033188 tegen griep

OSAKA, Japan-(BUSINESS WIRE)- Shionogi & Co., Ltd. heeft vandaag een presentatie aangekondigd over cefiderocol (S-649266), een experimentele siderofore cefalosporine in de laatste ontwikkelingsfase die actief is tegen uiteenlopende Gram-negatieve pathogenen, inclusief de ziekteverwekkers die zeer resistent zijn tegen het huidige aanbod geneesmiddelen, zoals colistine- en carbapenem-resistente strengen van de Pseudomonas aeruginosa, Acinetobacter baumannii, enterobacterien (CRE) en de Stenotrophomonas maltophilia. Daarnaast geeft het bedrijf een presentatie over S-033188, een experimentele cap-onafhankelijke endonuclease-inhibitor die is gericht op griep. Shionogi & Co., Ltd. geeft de presentaties op het European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), dat van 22 tot 25 april 2017 plaatsvindt in Wenen in Oostenrijk.

Shionogi presents New Data on Cefiderocol (S-649266), a Siderophore Cephalosporin, and S-033188 a Cap-Dependent Endonuclease Inhibitor for Treatment of Influenza at ECCMID 2017

OSAKA, Japan-(BUSINESS WIRE)- Shionogi & Co., Ltd. today announced it will be presenting new data on cefiderocol (S-649266), an investigational siderophore cephalosporin in late stage development with activity against a broad range of Gram-negative pathogens, including those highly resistant to currently available agents such as colistin and carbapenem-resistant strains of Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacteriaceae (CRE) and Stenotrophomonas maltophilia, and S-033188, an investigational cap-dependent endonuclease inhibitor targeting influenza at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), held in Vienna, Austria, April 22 - 25, 2017.

Highlights of cefiderocol presentations include first time clinical trial efficacy results, as well as supportive in vitro data, and S-033188 presentations will showcase both clinical and non-clinical data (e.g., non-clinical efficacy against avian influenza virus A/H5N1).

Below is an overview of the oral and poster presentations featuring cefiderocol and S-033188 at ECCMID 2017:

Cefiderocol Session Title Presentation Abstract Number & Presentation Information Abstract #7582 Cefiderocol Compared with Imipenem/Cilastatin in the Treatment of Adults with Complicated Urinary Tract Infections with or without Pyelonephritis or Acute Uncomplicated Pyelonephritis: Results Oral Presentation Late-breaker: Recent clinical trials from a Multicenter, Double-blind, Randomized Study (APEKS*-cUTI) Saturday, April 22, 2017 17:09-17:20 PM Presenter: Simon Portsmouth Abstract #3177 Mode of action of cefiderocol, a novel siderophore cephalosporin, active against highly resistant Gram-negative bacteria including carbapenem-resistant strains of Enterobacteriaceae and Oral Presentation Advances in Japanese Chemotherapy non-fermenting bacteria Monday, April 24, 2017 14:54-15:04 PM Presenter: Yoshinori Yamano Poster #1316 In vitro activity of cefiderocol against globally collected carbapenem-resistant Gram-negative bacteria including isolates resistant to ceftazidime/avibactam, ceftolozane/tazobactam and Poster Presentation colistin: SIDERO-CR-2014/2016 study Monday, April 24, 2017 12:30-13:30 PM Presenter: Yoshinori Yamano Poster #1314 Poster Presentation Cefiderocol Surveillance of cefiderocol in vitro activity against Gram-negative clinical isolates collected in Europe: SIDERO-WT-2014 Monday, April 24, 2017 12:30-13:30 PM Presenter: Masakatsu Tsuji Poster #1313 Poster Presentation The in vitro activity of cefiderocol, a siderophore cephalosporin, against a global collection of Stenotrophomonas maltophilia Monday, April 24, 2017 12:30-13:30 PM Presenter: Masakatsu Tsuji S-033188

Session Title Presentation Abstract Number & Presentation Information Abstract #1033 Pharmacokinetic/pharmacodynamic analysis of S-033188, an influenza Cap-dependent endonuclease inhibitor, from a phase 2, randomized, double-blind, placebo-controlled study in otherwise healthy Oral Presentation Advances in Japanese chemotherapy adults with seasonal influenza Monday, April 24, 2017 15:18-15:28 PM Presenter: Takeki Uehara Poster #1971 One day oral dosing of S-033188, a novel inhibitor of influenza virus Cap-dependent endonuclease, exhibited significant reduction of viral titer and prolonged survival in mice infected with Poster Presentation influenza B virus Tuesday, April 25, 2017 12:30-13:30 PM Presenter: Takao Shishido Poster #1973 Poster Presentation

Novel and improved therapeutical approaches to viral infections Pharmacokinetic and pharmacodynamic analysis of S-033188/S-033447, a novel inhibitor of influenza virus Cap-dependent endonuclease, in mice infected with influenza A virus Tuesday, April 25, 2017 12:30-13:30 PM Presenter: Takeshi Noshi Poster #1974 Poster Presentation Inhibitory effect of S-033188/S-033447, a novel inhibitor of influenza virus Cap-dependent endonuclease, against highly pathogenic avian influenza virus A/H5N1 Tuesday, April 25, 2017 12:30-13:30 PM Presenter: Keiichi Taniguchi

Cefiderocol--an investigational antibiotic agent ^1

Cefiderocol is a siderophore cephalosporin with a novel mechanism for efficiently penetrating the outer cell membrane of Gram-negative pathogens. Cefiderocol binds to ferric iron and is actively transported into bacterial cells through the outer membrane via the bacterial iron transporters which function to incorporate this essential nutrient for bacteria. ^2 This Trojan Horse strategy allows cefiderocol to achieve higher concentrations in the periplasmic space where it can then bind to receptors and inhibit cell wall synthesis in the bacterial cells. ^3 In addition, cefiderocol is stable against all known classes of beta-lactamases, including both the metallo- and serine-carbapenemases. ^4 Data from global surveillance studies for cefiderocol demonstrated potent in vitro activity against a wide spectrum of Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae and Stenotrophomonas maltophilia. ^5

About the regulatory pathway of cefiderocol

Cefiderocol is currently in clinical development and recently completed a US registrational study in patients with cUTI (APEKS*-cUTI). An additional Phase 3 trial in patients with carbapenem-resistant pathogens at various infection sites (CREDIBLE-CR) is ongoing. In 2017 Shionogi will initiate a Phase 3 HAP/VAP/HCAP/- (APEKS*-NP/=) clinical trial. The Company plans to submit a new drug application to the U.S. FDA in 2017 and to the EMA in 2018. Information is available at www.clinicaltrials.gov under the identifiers NCT02321800, NCT02714595 and NCT03032380, respectively.

* Acinetobacter, Pseudomonas, Escherichia, Klebsiella and Stenotrophomonas

^/-Hospital-Acquired Pneumonia/Ventilator-Acquired Pneumonia/Healthcare-Associated Pneumonia

^/= Nosocomial Pneumonia

About Influenza

Epidemic and pandemic influenza remain a major public health concern, and novel influenza drugs that will offer significant improvement over current therapy are urgently needed. Worldwide, annual influenza epidemics are estimated to result in 3 to 5 million cases of severe illness, and about 250,000 to 500,000 deaths. ^6 In general, those at highest risk of influenza-associated complications include children under 2 years of age, adults over 65 years of age, pregnant women, and people of any age with certain medical conditions, including chronic heart, lung, metabolic diseases (such as diabetes) and weakened immune systems.

About S-033188

S-033188 is a cap-dependent endonuclease inhibitor with a novel mechanism of action being studied for the treatment of influenza. S-033188 is an investigational product being developed for one-time dosing, and has the potential to be more effective than existing marketed anti-influenza products. Development and commercialization are in collaboration with F. Hoffmann-La Roche Ltd.

About Shionogi

Shionogi & Co., Ltd. is a major research-driven pharmaceutical company dedicated to bringing benefits to patients based on its corporate philosophy of "supplying the best possible medicine to protect the health and well-being of the patients we serve." Shionogi's research and development currently target two therapeutic areas: infectious diseases, and pain/CNS disorders. For over 50 years, Shionogi has developed and commercialized innovative oral and parenteral anti-infectives. In addition, Shionogi is engaged in new research areas, such as obesity/geriatric metabolic disease and oncology/immunology. Contributing to the health and quality of life of patients around the world through development in these therapeutic areas is Shionogi's primary goal. For more details, please visit www.shionogi.co.jp/en/. For more information on Shionogi Inc., the U.S.-based subsidiary of Shionogi & Co., Ltd., headquartered in Florham Park, NJ, USA, please visit www.shionogi.com. For more information on Shionogi Ltd., the UK-based subsidiary of Shionogi & Co. Ltd., headquartered in London, England, please visit www.shionogi.eu.

Forward Looking Statement

This announcement contains forward-looking statements. These statements are based on expectations in light of the information currently available, assumptions that are subject to risks and uncertainties which could cause actual results to differ materially from these statements. Risks and uncertainties include general domestic and international economic conditions such as general industry and market conditions, and changes of interest rate and currency exchange rate. These risks and uncertainties particularly apply with respect to product-related forward-looking statements. Product risks and uncertainties include, but are not limited to, completion and discontinuation of clinical trials; obtaining regulatory approvals; claims and concerns about product safety and efficacy; technological advances; adverse outcome of important litigation; domestic and foreign healthcare reforms and changes of laws and regulations. Also for existing products, there are manufacturing and marketing risks, which include, but are not limited to, inability to build production capacity to meet demand, unavailability of raw materials and entry of competitive products. The company disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

References

1. Kohira N, West J, Ito A, et al. In vitro antimicrobial activity of a siderophore cephalosporin, S-649266, against Enterobacteriaceae clinicalisolates, including carbapenem-resistant strains . Antimicrob Agents Chemother. 2015;60(2):729-734.

2. Ito A, Nishikawa T., Masumoto S, et al. Siderophore Cephalosporin Cefiderocol Utilizes Ferric Iron Transporter Systems for Antibacterial Activity against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016;60(12).

3. Tillotson GS. Trojan Horse Antibiotics--A Novel Way to Circumvent Gram-Negative Bacterial Resistance? Infectious Diseases: Research and Treatment. 2016;9:45-52 doi:10.4137/IDRT.S31567.

4. Ito-Horiyama T, Ishii Y, Ito A, et al. Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases. Antimicrob Agents Chemother. 2016;60(7):4384-4386.

5. M Hackel, M Tsuji, Y Yamano, et al. In Vitro Activity of the Siderophore Cephalosporin, Cefiderocol, Against a Recent Collection of Clinically Relevant Gram-Negative Bacilli from North America and Europe, Including Carbapenem Non-Susceptible Isolates: The SIDERO-WT-2014 Study. Antimicrobial Agents Chemotherapy (In preparation)

6. http://www.who.int/mediacentre/factsheets/fs211/en/ WHO website, Influenza (Seasonal), Fact sheet NDEG211, March 2014

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Contacts

Shionogi & Co., Ltd.

Corporate Communications

+81-6-6209-7885

Fax: +81-6-6229-9596

or

Investor Relations

Shionogi & Co., Ltd.

Yoshimasa Kyokawa, +81-6-6209-7885

Associate Director of Corporate Communications

yoshimasa.kyokawa@shionogi.co.jp< /a>

or

Shionogi Inc. U.S. Media

Michele Mencer, +1-973-307-3353

Vice President

Michele.mencer@shionogi.com